|
KMID : 0525720180230030170
|
|
Journal of Chitin and Chitosan
2018 Volume.23 No. 3 p.170 ~ p.175
|
|
|
Anti-inflammatory Effects and Influence on Fibroblast Growth of Astaxanthin-Cyclodextrin Nanoparticles
|
|
Kim Jin
Lee Chang-Moon
|
|
|
Abstract
|
|
|
|
In this study, we investigated anti-inflammatory effects and influence on fibroblast growth of astaxanthin-loaded hydroxypropyl- β-cyclodextrin nanoparticles (Ast-CD NPs). Astaxanthin was included into the cavity of hydroxypropyl-β-cyclodextrin. Ast-CD NPs have spherical shape and were stable in aqueous solution for 28 days without mean diameter changes and precipitation. Ast-CD NPs inhibited nitric oxide and prostaglandin E2 production induced by lipopolysaccharide in RAW264.7 cells in a concentration-dependent manner. From NIH 3T3 fibroblasts closed scratch assay, the scratch distance was narrowed significantly according to the concentration of Ast-CD NPs. These results indicate that Ast-CD NPs may be helpful for biomedical applications such as drug delivery, wound healing, and cosmetics.
|
|
|
KEYWORD
|
|
|
Asatxanthin, Cyclodextrin, Nanoparticles, Anti-inflammatory effect, Cell migration
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|